Indications

Diloren (Diclofenac Sodium) is indicated for:

Rheumatology

Inflammatory and degenerative rheumatic disorders.
Chronic polyarthritis.
Ankylosing spondylitis.
Osteoarthritis.
Spondylarthrosis.
Acute gout.
Peri-articular rheumatic disorders.

Surgery and Traumatology

Sprains.
Bruises.
Dislocations.
Fractures.
Soft tissue injuries.
Surgical interventions.

Obstetrics and Gynecology

Primary dysmenorrhoea.
Episiotomy.
Adnexitis.
Endometritis.
Parametritis.
Salpingitis.
Mastitis.

Otorhinolaryngology (ENT)

Pre-operative prevention of pain, inflammation, and swelling.

Dentistry

Post-operative and post-traumatic pain, inflammation, and swelling.

Other Indications

Prevention of pain and treatment of inflammation and swelling after urogenital surgery.
Renal colic.
Biliary colic.

Pharmacology

Diclofenac Sodium is a potent non-steroidal anti-inflammatory drug (NSAID) with anti-rheumatic, anti-inflammatory, analgesic, and antipyretic properties. It also possesses mild uricosuric activity. Diclofenac works by inhibiting prostaglandin synthesis, which plays an important role in causing pain, inflammation, and fever. It is rapidly and completely absorbed from the gastrointestinal tract when taken with or after meals. Peak plasma concentrations are achieved within approximately 2 hours after administration. About 99.7% is bound to plasma proteins at therapeutic concentrations. Diclofenac is metabolized in the liver and undergoes first-pass metabolism.

Dosage & Administration

Diclofenac FC Tablet

Adults: 75-150 mg daily in 2-3 divided doses, preferably after meals.
Dose reduction is recommended during long-term therapy.

Diclofenac SR Tablet

Adults: 1 tablet daily, preferably with meals. Dose may be increased to 150 mg daily if necessary.
Children: 1-3 mg/kg body weight daily in divided doses.
Elderly: Use the lowest effective dose.

Diclofenac Dispersible Tablet (DT)

Adults: 2-3 tablets daily; maximum dose 150 mg daily.
Mild cases may require only 2 tablets daily.
Preferably taken before meals.
Children: 1-3 mg/kg body weight daily for juvenile rheumatoid arthritis only.
Dissolve the tablet in half a glass of water, stir well, and drink immediately.

Diclofenac TR Capsule

One capsule daily, preferably after meals.

Diclofenac Suppository

Adults: 50 mg suppository 2-3 times daily.
Maximum daily dose: 150 mg.

Diclofenac Injection

Adults: 1 ampoule daily.
Severe cases: Up to 2 ampoules daily.

Diclofenac Gel

For external use only.
Apply 2-4 g of gel to the affected area 3-4 times daily and rub in gently.
Can be used alongside other dosage forms of Diclofenac.

Drug Interactions

Lithium and Digoxin: May increase plasma concentrations.
Anticoagulants: May increase the risk of bleeding.
Antidiabetic Agents: Generally can be used together without affecting clinical efficacy.
Cyclosporin: Increased risk of nephrotoxicity.
Methotrexate: Increased risk of serious toxicity.
Quinolone Antibiotics: May increase the risk of convulsions.
Other NSAIDs and Steroids: May increase adverse effects.
Aspirin: May lower plasma levels of both drugs.

Contraindications

Hypersensitivity to Diclofenac or any component of the formulation.
Active peptic ulcer disease.
Patients with a history of asthma, urticaria, or acute rhinitis precipitated by aspirin or other NSAIDs.
Diclofenac Gel should not be used under occlusive airtight dressings.