Indications

Glyset Vita SC Injection is an insulin analog indicated to improve glycemic control in patients with diabetes mellitus.

Composition

Each ml solution contains 100 IU (equivalent to 3.50 mg) Insulin Aspart (rDNA).

Description

Glyset Vita rDNA is a sterile, clear solution of Glyset Vita human insulin analogue for subcutaneous injection/infusion or intravenous injection. This is a blood glucose lowering agent with an earlier onset
of action. It produces a more rapid onset of action compared to soluble human insulin. Glyset Vita is homologous with regular human insulin with the exception of a single substitution of the amino acid
Proline by aspartic acid in position B28, and is produced by recombinant DNA technology.

Pharmacology

The primary activity of Insulin Aspart is the regulation of glucose metabolism. Insulin Aspart bind to the insulin receptors on muscle and fat cells and lower blood glucose by facilitating the cellular
uptake of glucose and simultaneously inhibiting the output of glucose from the liver.

Dosage

Insulin Aspart has a faster onset and a shorter duration of action than soluble human insulin. Due to the faster onset of action, Insulin Aspart should generally be given immediately before a meal. When
necessary Insulin Aspart may be given soon after a meal.

Dosage of Insulin Aspart is individual and determined on the basis of the physician's advice in accordance with the needs of the patient. It should normally be used in combination with long-acting
insulin given at least once a day.

The individual insulin requirement is usually between 0.5 and 1.0 IU/kg/day in adults and children over 2 years of age. In a meal-related treatment 50-70% of this requirement may be provided by Insulin
Aspart and the remainder by long-acting insulin. Adjustment of dosage may also be necessary if patients undertake increased physical activity or change their usual diet. Exercise taken immediately
after a meal may increase the risk of hypoglycaemia.

Subcutaneous Injection: Insulin Aspart should be administered by subcutaneous injection in the abdominal region, buttocks, thigh, or upper arm. Because Insulin Aspart has a more rapid onset and a
shorter duration of activity than human regular insulin, it should be injected immediately (within 5-10 minutes) before a meal Continuous Subcutaneous Insulin Infusion (CSII) by External Pump Insulin
Aspart can also be infused subcutaneously by an external insulin pump. The initial programming of the external insulin infusion pump should be based on the total daily insulin dose of the previous
regimen. Approximately 50% of the total dose is usually given as meal-related boluses of Insulin Aspart and the remainder is given as a basal infusion. When used with an infusion pump Insulin Aspart
should not be mixed with any other insulin.

Intravenous Use: Insulin Aspart can be administered intravenously under medical supervision for glycemic control with close monitoring of blood glucose and potassium levels to avoid hypoglycemia
and hypokalemia. For intravenous use, Insulin Aspart should be used at concentrations from 0.05 IU/mL to 1.0 IU/mL insulin aspart in infusion systems using polypropylene infusion bags. Insulin Aspart
has been shown to be stable in infusion fluids such as 0.9% sodium chloride.

Administration

Instructions to be given to the patient before injecting this Insulin:
. According to the instruction given with ConviPen, insert the cartridge into the pen correctly & equip the needle
. Gently turn the pen upside down for 8-10 times until the insulin in the cartridge becomes uniformly mixed suspension
. Remove the needle cap, discharge air bubbles in the catridge
. Adjust the dosage button to get correct dose & inject to the specific site
. In order to avoid cross contamination, do not let the needle touch anything during the process of preparation.