Indications

Synogen capsule is indicated for-
. Osteoarthritis
Rheumatoid arthritis
Joint pain & inflammation
. Difficulties in flexibility & mobility
. Joint discomfort & stiffness (knee extension)
. Impaired joint function
. Strenuous exercise & sports

Composition

Each 40 mg capsule contains following nutritional facts-
. Calories: 2.7 Cal
. Calories from Fat: 0 Cal
. Total Fat: 0 Cal
. Saturated Fat: 0 Cal
Trans Fat: 0 Cal
. Cholesterol: 0.01 mg
Total Carbohydrate: 5 mg
. Sugars: 0 mg
Dietary Fiber: 5 mg
Protein: 17 mg
Calcium: 0.04 mg
· Sodium: 0.51 mg
Iron: 0.001 mg
. Chloride: 5.64 mg
. Potassium: 6.92 mg

Pharmacology

Undenatured Type II Collagen derived from chicken sternum cartilage using a patented, low-temperature, non-enzymatic manufacturing process that preserves the natural triple helix molecular
configuration and its biological activity. Undenatured collagen II has unique mechanism of action. Undenatured collagen II molecules contain active binding sites called epitopes which trigger the
process of oral tolerization. Through oral tolerization process, active epitopes of undenatured collagen II interact with Peyer's patches (lymphoid tissue) of small intestine to release collagen-specific
regulatory T-cells. Collagen-specific regulatory T-cells then migrate to joint areas and prevent release of T-cells.

Preventing the release of T-cells prevent the secretion of collagenase enzymes by macrophages responsible for breakdown of collagen in joint cartilage. It also slows the production of inflammatory
cytokines resulting in reduction of inflammation, halting the erosion of joint cartilage and promote cartilage rebuilding. Undenatured Type II Collagen supports joint function, mobility and flexibilityand
also improves knee extension by up to 10% for better range of motion. It also relieves joint pain due to strenuous exercise.

Dosage & Administration

Orally 1 capsule daily with water or as directed by the physician.

Interaction

Not known.

Contraindications

Contraindicated in patients with known hypersensitivity to chicken or egg.