Indications

This is indicated as a daily multivitamin maintenance dosage for adults and children aged 11 years and above receiving parenteral nutrition. It is also indicated in other situations where administration by
the intravenous route is required. Such situations include surgery, extensive burns, fractures and other trauma, severe infectious diseases and comatose states, which may provoke a "stress" situation
with profound alterations in the body's metabolic demands and consequent tissue depletion of nutrients.

Composition

Each vial contains:
Vitamin A BP 3500 IU
Vitamin D3 BP 220 IU
Vitamin E USP 11.2 IU
Ascorbic Acid BP 125 mg
Vitamin B1 BP 3.51 mg
Vitamin B2 BP 4.14 mg
Nicotinamide BP 46 mg
. Pantothenic Acid BP 17.25 mg
. Vitamin B6 BP 4.53 mg
Vitamin B12 BP 6 mcg
. Folic Acid BP 414 mcg
Biotin BP 69 mcg.

Description

This is a sterile, lyophilized powder for injection/infusion which contains nine water-soluble and three fat soluble vitamins. Mixed micelles is used as a solubilizing agent. It is presented as a lyophilized,
sterile powder that is to be reconstituted with 5ml of Water for injections or other parenteral fluids (e.g. as 0.9% Sodium chloride or 5% Glucose solution), prior to administration by parenteral route.

Pharmacology

This is a sterile, lyophilized powder for injection/infusion which contains nine water-soluble and three fat soluble vitamins. Mixed micelles is used as a solubilizing agent. It is presented as a lyophilized,
orange-yellow, sterile powder that is to be reconstituted with 5ml of Water for injections or other parenteral fluids, (e.g. as 0.9% Sodium chloride or 5% Glucose solution), prior to administration by
parenteral route.

Dosage & Administration

Adults and children aged 11 years and above: 1 vial/day. The single dose vial is reconstituted by adding 5 ml of sterile Water for injection or other intravenous fluids like 0.9% Sodium Chloride injection or
5% Glucose injection. 5 ml of diluent should be added by means of sterile syringe into the vial and gently mixed to dissolve the lyophilized powder. The entire volume of the resultant solution should then
be administered by slow Intravenous injection (at least over 10 minutes) or further diluted for intravenous infusion. To minimize vitamin losses in parenteral nutrition admixtures, add the vitamins
immediately prior to administration and complete administration within 24 hours.

Interaction

Patients receiving drugs that bind to a1-acid glycoprotein should be closely monitored for increases in response to these drugs, e.g. propranolol, prazosin and quinidine. Folic acid may increase the
metabolism of some antiepileptics, such as phenobarbital, phenytoin and primidone. Pyridoxine can reduce the effect of levodopa. Bleomycin can be inactivated by ascorbic acid and riboflavin.

Contraindications

This is contraindicated in patients with pre-existing hypervitaminosis or known hypersensitivity to any of the active ingredients. This product should not be injected to patients with pre-existing
intolerance to thiamine. Similarly, this product should not be administered to patients with impaired hepatic function. This preparation should not be
administered to those suffering from hyperparathyroidism due to hypercalcaemic complications.