Indications

Pearl-B is indicated in-
. Hair loss
. Weak, brittle, splitting or soft nails
· Eczema & dermatitis.

Pharmacology

Biotin is an essential vitamin that is also known as vitamin H. It is involved in vital physiological function like fatty acid synthesis, amino acid catabolism and gluconeogenesis. It acts as a cofactor in the
enzymatic carboxylation of pyruvate and acetyl-CoA. Biotin influences the growth and differentiation of epidermal cells and is therefore important for the formation and renewal of the skin, hair and
nails. It functions as a coenzyme for mitochondrial carboxylases in hair roots and improves the keratin structure. Biotin deficiency may result in hair loss and a variety of systemic symptoms such as
dermatitis, and aciduria. Biotin is one of the most prescribed nutritional supplements for any kind of hair loss.

Dosage & Administration

Biotin dose varies depending on disease condition and age group.

In adults: Generally 1-3 tablets per day or as advised by the physician.

In children: biotin deficiency affects between 1 week and 2 years of age and usually exhibits seizures, hypotonia, developmental delay, ataxia, hyperventilation, and coma. In this case, 5-10 tablets daily,
crushed and mixed with water or any kind of fruit juice or as advised by the physician.

Recommended dietary allowance:

Infants-
- 0-6 months: 5 mcg/day
- 7-12 months: 6 mcg/day

Children-
. 1-3 years: 8 mcg/day
. 4-8 years: 12 mcg/day

Males and females-
9-13 years: 20 mcg/day
. 14-18 years: 25 mcg/day
. 219 years: 30 mcg/day
Pregnancy: 30 mcg/day

Lactation: 35 mcg/day

Interaction

There are indications that anticonvulsant drugs lower the plasma level of Pearl-B. Antibiotic use may decrease the Pearl-B contribution to the body made by the microflora of the large intestine.
Excessive consumption of raw egg whites interferes with Pearl-B absorption.

Contraindications

Contraindicated in patients with known hypersensitivity to any of the ingredients.

Side Effects

Well tolerated in the recommended dose. No Pearl-B toxicity has been reported in individuals supplemented with as much as 200 mg orally or 20mg intravenously per day.