Indications
Zyrolin is indicated for the treatment of:

Nosocomial pneumonia
Community-acquired pneumonia
Complicated skin and soft tissue infections including diabetic foot infections without osteomyelitis
Uncomplicated skin and soft tissue infections
Infections caused by vancomycin-resistant Enterococcus faecium

Limitation of Use
Zyrolin is not effective against Gram-negative infections
Safety and efficacy beyond 28 days have not been established

Pharmacology
Linezolid is a synthetic antibacterial agent belonging to the oxazolidinone class

Activity

Dosage and Administration

General

Adults and Adolescents (12 years and older)

Pediatric Patients

Neonates

Drug Interactions
Linezolid is a reversible MAO inhibitor

Avoid or use caution with

Risk includes serotonin syndrome and hypertensive reactions

Food Interaction
Avoid high tyramine foods such as aged cheese and fermented products

Contraindications

Side Effects
Common

Other effects

Pregnancy and Lactation

Pregnancy
Use only if benefit outweighs risk

Lactation
Passes into breast milk
Monitor infant for diarrhea and vomiting

Precautions and Warnings

Overdose
No specific antidote
Supportive care is recommended
Approximately 30 percent removed by hemodialys